NEURO-GENSEQ - Informatics interrogation for rapid precision genetic diagnosis

Congenica and FutureNeuro have announced the first stage of their ground-breaking partnership to develop new, automated tools to assist in the diagnosis of epilepsy, whilst integrating them with Ireland’s Electronic Health Record (EHR) system.

The partnership will develop a cutting-edge clinical decision platform for epilepsy, harnessing the power of Congenica’s clinical genomics analysis software, Sapientia, to better target and diagnose epilepsy in patients.

Run over two years, the project will operate out of the FutureNeuro lab in Dublin, which is an SFI Research Centre dedicated to developing new technologies and solutions for the treatment, diagnosis and monitoring of chronic and rare neurological diseases.

Congenica will develop new tools that will come together to create a diagnostic support platform spanning the entire workflow from DNA sequencing to integrating the final data with the Irish national electronic health record (EHR).

The first stage of the project will centre upon the transfer of numerous epilepsy exomes and genome-wide association study (GWAS) datasets, into Sapientia. Further data will be uploaded in the form of more GWAS and whole exome sequence (WES) datasets, all of which will be available to the clinical scientists throughout their research, combined with Sapientia’s existing knowledge base of high quality epilepsy data.

Security of the data will be ensured by Sapientia’s own robust, secure cloud-based environment, which encrypts all data and connections both in transit and at rest, but also by careful collaboration between FutureNeuro’s and Congenica’s in-house quality control experts.

Ant Rogers, Head of Bioinformatics at Congenica, said: “The ultimate goal of the project will be the development of a bioinformatics pipeline within Sapientia to detect somatic mutations in epilepsy, specifically malformations of cortical development (MCD), which are an important pathological feature of the condition. In fact, MCD’s are thought to be the root of as much as 40% of refractory childhood epilepsy.”

“Presently, the tests to diagnose epilepsy, such as EEG’s, CT scans or MRI’s amongst others, are slow, inaccurate and only available or applicable after someone has started experiencing seizures, which in many cases may be too late. We are very excited about the new project with FutureNeuro SFI Research Centre and what these breakthroughs could mean for patients and their families around the world.” He continued.

In the long term, the project will see Sapientia, which was born out of a pioneering research project at the Sanger institute, being enhanced to help clinicians and geneticists interrogate DNA sequences for somatic epilepsy in a clinical context. These enhancements will be integrated with the Irish EHR and will be crucial to developing diagnoses and treatments for patients with neurological conditions.

David Henshall, FutureNeuro’s Centre Manager, said: “FutureNeuro brings together an exceptional team of scientists, clinicians and other experts to address the urgent needs of patients with chronic and rare neurological diseases such as epilepsy and motorneurone disease. In a globally unique way, the Centre will undertake cutting-edge research on diagnosis and treatment of neurological disorders that leverages the emerging electronic healthcare infrastructure in Ireland. With our industry partners and hospital network, we can more quickly translate research into effective diagnostic supports, treatments and monitoring systems that will benefit the lives of patients living with these debilitating and often devastating conditions that impact more than 700,000 people in Ireland.”

Epilepsy affects more than 50 million people worldwide, making it one of the most common neurological conditions. Though it can be managed, the condition can be particularly damaging to children who may only display symptoms upon their first fit, which carries a high potential risk of brain damage to the patient. It is in the early diagnoses of such cases that the project would see its greatest impacts as the first fit carries the highest risk of catastrophic consequences.

Dr. Charles Steward, Congenica’s scientific lead on the project said: “In the future, the work we do will help establish if a child has a de novo mutation or not, meaning that recurrence risk is low in other children. It will help to allow prenatal diagnosis for future children and to tailor treatments, such as drug repurposing, based on a disease defined by a gene’s erroneous sequence. Furthermore, when a patient is referred to a clinician, there will be

much richer data sources to inform on the consultation. For example, these would be things like electronic health records that integrate results of genomic sequencing with other data sources, such as MRI.”

Ireland’s science strategy, known as innovation 2020, aims to build the total investment in research and development, in both the public and private sectors, to 2.5% of their gross national product (GNP). SFI announced in May of this year that it will invest €72 million over the next six years in four new world-class SFI Research Centres in Ireland.

SFI’s Director General, Dr. Mark ferguson, said: “Our existing 12 SFI Research Centres are outstanding international examples of applied and basic combined (ABC) research. They are making important scientific advances, enhancing enterprise and industry, developing critical skills, supporting regional development, and enhancing Ireland's international reputation. They are drivers of Ireland's increased rankings in research and innovation over the last number of years. They are also an important engine for the economy; companies engaged with the SFI Research Centres are located all over Ireland and the world. The commitment of industry and academic bodies to come together to develop these new SFI Research Centres clearly demonstrates the potential economic and societal impact of the planned research.”

Congenica welcomes Chinese trade delegation to Cambridge Headquarters.

A delegation of eminent government and business representatives from one of China’s most vibrant and innovative cities has visited Congenica, at their Cambridge HQ, to discuss potential future collaborations as the exciting start-up expands into China.

The delegation was led by Qingdao’s Mayor, Meng Fanli, who was accompanied by representatives of the Qingdao Municipal Government, Qingdao Bureau of Commerce, the President of Qingdao’s Sino-German Eco Park, Qingdao Foreign Affairs Office and members of the Beijing Genomics Institute (BGI), the latter of whom are both a partner of Congenica and have recently opened offices in the city.

The meeting, held at Congenica international headquarters at the Wellcome Trust Genome Campus, Cambridge, focused on an overview of Congenica’s gold standard clinical genomic analysis platform, Sapientia, from the company’s President Dr. Tom Weaver. Mayor Meng then went on to speak about Qingdao's vibrant and expanding science parks, increasing foreign capital and direct investment alongside major Chinese businesses, prestigious universities and direct global transport links.

“We have made a promise to the people to increase their standards of living and we have done that, but we have more to do. People’s demands have also increased so we will promise to provide genetic testing for all newborns in Qingdao. With BGI and their partner, Congenica we expect to complete this project.” Said Mayor Meng.

Qingdao has a history of trade and innovation both internationally and domestically. With its nearby international ports and airports, proximity to North and South Korea and also major domestic hubs such as Tianjin, Beijing and Shanghai, mean that it is consistently one of the highest GDP cities in the country. Chinese internet giant Baidu has recently signed a deal with the municipal government to turn it into China’s first smart city.

The other cities receiving attention from the central government and also vying to be the location of Congenica’s Chinese headquarters are Nanchang, Jiangxi, Ningbo, Zhejiang, and Suzhou, Jiangsu.

“The UK is widely respected around the world for our research and innovation,” said Rt Hon David Willetts MP, Minister of State for Universities and Science from 2010 to 2014. “By supporting the development of innovation capacity in other countries we can make it easier for UK businesses and universities to build links with counterparts overseas. The UK Science Park Association is a good example of this. Their work with the Chinese Association of University-based Science Parks has been highly valued by the Chinese Government.”

Mayor Meng and his delegation went on to London where he spoke the following day at the Qingdao Forum on UK - China Trade and Investment. “It is very impressive to see the use of innovation in supporting long term economic growth for England. Our mission is to support the economic development of China for its people, especially healthcare, through new technologies and ideas.”

Congenica addresses genetic testing of inherited diseases at 2nd International 4P Health Summit Forum 2017 in China

Congenica has continued to embrace their global mantle as they presented at a leading Chinese personalised medicine conference, which also hosted the renowned Leroy Hood of the Institute for Systems Biology and the P4 Medicine Institute. The event was attended by hundreds of prominent Chinese geneticists, clinicians and scientists gathered in the southern city of Tonglu, Zhejiang on Nov 14th, 2017.

Dr. Bai Shizhong, President of the China Health Promotion Foundation and Dr. Zhang Shibin, Chairman of the Chinese Health Management Association Steering Committee performed the opening ceremony highlighting the growing evidence of how genetics is playing an ever increasing role in wellness and diagnosing diseases.

Personalised medicine has been growing in eminence in China as the country modernises its vast healthcare system. Combined with the declining cost of sequencing a human genome and a greater understanding of genetic basis of diseases, the country’s scientists are driven to bring together the best minds, technologies and ideas in the field of genomics.

Congenica’s expertise in diagnosing inherited diseases by analyzing patient derived genomic data was highlighted at this forum. The company’s Chief Business Officer, Dr Shikha O'Brien, presented the ground-breaking work being done by the U.K. based company utilising their gold standard clinical genomics analysis platform, Sapientia. Dr. O’Brien spoke about the prevalence of rare diseases around the world and the sheer scale of sufferers in China - estimated to be around 16 million people. She then went on to show how Congenica’s clinical expertise in rare diseases combined with the interpretation technology platform can empower China’s genetic experts and hospitals to truly make an impact on the country’s healthcare.

Dr. O’Brien, said: “We are delighted to be part of this thought leadership in China and presenting at this conference. This is an opportunity for us as a community to realize the benefits of fast moving technologies in genomics. Accurate and fast interpretation of genomic data remains a bottleneck and Congenica’s technology is addressing that gap with demonstrated success across a wide variety of applications in diagnoses of rare disease.”

Dr O’Brien presented several examples where Sapientia platform was critical in a fast turnaround with clinically actionable reports in rare disease pediatric patients for whom fast and accurate diagnosis is key. She provided additional examples where the Sapientia platform is being used in diagnostics and pharmaceutical drug discovery as well as clinical trials design using genetics based risk factors in patient cohorts.

The conference also saw a number of presentations from members of the Chinese Academy of Sciences’ Hundred Talents Project, for which Dr. Hood was a researcher earlier in his career. The project describes itself as; ‘the backbone program for attracting and training academic and technological leaders’ both from domestic graduates and those attracted back from overseas, by offering benefits and preferential treatment in their professional and private lives.

Tonglu has seen a high level of investment in recent years, culminating with the construction of the Kona Tai 4P Medical Health Industry Park amongst a number of other high profile projects. Zhu Hua, Secretary of the County Party Committee, said: “Tonglu is a new talent city with a bright future. With the concept of talent as the first resource, science and technology as the first productive force, and innovation as the first driving force, we will create the best talent ecology.”

A number of awards were also presented at the conference to outstanding Chinese scientists and entrepreneurs in healthcare and its associated fields.

Sanger Institute welcomes San Diego trade delegation

Congressman Peters addresses representatives of Genomics England, Illumina and Edico amongst others

Congressman Peters addresses representatives of Genomics England, Illumina and Edico amongst others

The Wellcome Sanger Trust welcomed a US Congressman and trade delegation from the city dubbed, ‘America’s genomics capital’, for a discourse on innovation and enterprise in the life sciences, last week(18/10).

The delegation was composed of a mixture of government and business representatives from the UK and San Diego, including the city’s Regional Economic Development Corporation (SDREDC), who organised the event, Genomics England, Edico Genome, Congenica and led Congressman, Scott Peters (Dem. CA-52).

San Diego has re-invented itself over the previous decades as a 21st century smart city, embracing science, technology, engineering and mathematics (STEM) in its business, education and amenity planning and now challenges San Francisco as a centre for trade and technology on the west coast.

The two cities hold key positions in both the current life science industries and in the history of the discipline as a whole. Both were the sites of key events on the science’s timeline and home to the biggest names in the industry. They have created environments which attract lots of venture capital and are magnets for talent. Supported by high quality universities and institutes, they are perfect locations to grow spin-outs and start-ups such as Congenica.

“I think we are all impressed by the parallels between Cambridge and San Diego. Two vibrant, dynamic cities both excited about science and innovation, particularly in the genetics and STEM fields. Life sciences have $5.6 billion of economic impact in our city and that includes heavyweights like Illumina but also relative newcomers such as Edico who has proved its processor with an impressive growth trajectory through their work with Congenica.” Said. rep. Peters.

Before the Congressman spoke the gathered representatives of government and industry had heard from Prof. Joanna Hackett, Chief Commercial Officer of Genomics England, who said: “There are three groups here today who have saved a lot of lives. Congenica, Edico and Genomics England. Whole genome sequencing will become routine clinical care, our project has proved its clinical utility. Genomics England is very good at getting the patients, our population is very rich, but we need to rely on other companies to extract and interpret the data and that is where the great work of our partners such as Congenica comes in.”

Life sciences are highly prized industries for modern cities. The jobs created in these sectors tend to be high wage and knowledge intensive but still provide a highly deployable skillset. They are strong attractors of talent and drivers of education as well as having some of the highest numbers of spin-out companies to keep the market growing and diverse.

The city boasts a huge number of ultra-modern solutions such as one of the world’s largest internet of things (IoT) networks which includes smart buildings, streetlights and utility metres. The city has embraced the electric car with 727 charging stations, with a number being directly powered by solar energy and more than 14,000 vehicles on the road. All of this and future innovation is underpinned by a reinvigorated education system capped by the city's university, UC San Diego which is part of the famous University of California group that includes Berkeley and UCLA.

Rebecca Hemenway, Senior Director of New Product and Business Development at Edico Genome told the audience: “The Human Genome Project took 13 years and $2billion to give a result. Now, it's very different. In fact, we hold the world record for performing the fastest genetic diagnosis at 26 hours from beginning to end. It is very important to have a streamlined and efficient workflow and that was why we established our partnership with Congenica. We expedite and they interpret.”

Closing the talks was Congenica’s Chairman, Dr. Andy Richards, who said: “Doing something like this, revolutionising healthcare, requires real ambition. Genomics England was a brave move on the part of the UK but it has unequivocally shown that genomics can make a real difference in healthcare. As much as our sector was born of the competition between Craig Venter and the private sector against institutes like the one we stand in now. It has been collaboration which has brought us to where we are today and which will take us to greater heights in the future.”

Congenica has been expanding into new territories over recent years and have seen their first strategic appointments on both the east and west coasts of the US, with most of them being based out of San Diego. The Cambridge based company has also seen its initial appointments in China too, where they also have partner organisations in the form of the Beijing Genomics Institute.

Rare Revolution Magazine - Bench to Boardroom

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When they found themselves part of a rare disease family, two sisters from Scotland took matters into their own hands setting up their own charity and magazine to raise awareness. Now, they are speaking to some of the leading minds in genomics as they addressed the latest Bench to Boardroom lecture at the Wellcome Trust Genome Campus last week (24/10).

“It seems strange to hear ourselves referred to as entrepreneurs and to be here now talking to people who are experts in their fields. Maybe we have a bit of imposter syndrome? But therein lies the crux of what we’ll talk about today, it's the experience and knowledge of the patients themselves and those closest to them which is so often not fully utilised.”

Nicola Miller and Rebecca Stewart established the Teddington Trust charity in 2012, in the wake of Nicola’s son’s diagnosis with Xeroderma Pigmentosum (XP) as a way of both communicating the condition to her son and raising awareness for others around them.

The condition is an autosomal recessive disorder in which cells lack the ability to repair the damage caused by ultraviolet (UV) light. This can lead to sufferers developing multiple basal cell carcinomas and other dangerous skin malignancies which commonly affect the patient at a young age forming metastatic malignant melanoma and squamous cell carcinoma, sadly, the most common causes of death amongst those afflicted.

There are currently tragically few treatment options available for the condition, and sufferers must wear protective clothing any time they are outside and even in some indoor environments.

Little Ted is the star of the Teddington Trust books and stories, which focus on teaching those affected by the condition and normalising it for children struggling with it. Nicola’s Little Ted books have won a British Medical Association award for their accessible, well designed and clinically balanced patient relevant information.

The two sisters went on to launch their magazine, Rare Revolution, in the Autumn of 2016. “We were motivated to start the magazine because we had a hit a few hurdles in communicating through the charity,” said Rebecca Stewart. “It's difficult, with such personal stories about such rare conditions, to stop them becoming a ‘woe is me’ human interest story. We had received interest from the mainstream press before but it was harnessed in a negative light. The problem is that they have to control the message, the subject of a story will never have any power. The press’s responsibility is to the news cycle. The coverage they produce also betrays the trust of their subjects and this gets very messy when there are children involved. They always disappoint, they have a 100% record across our community.”

“At first we imagined a glorified newsletter. We initially built it up from the community on our Facebook page but we really wanted to create a multi-stakeholder environment.” Said Rebecca Stewart. “That community was one of the most unexpected things about it has also become one of the most powerful. We received one video message from a reader about how it had affected him and it was a very...raw message. We knew then that we were on the right track. So we have been working to create that space for the community across different rare disease groups and not just here, we have readers all around the world, it's a global community.”

The success they had seen both in the magazine itself and the surrounding community inspired them to start planning for the first edition of the magazine focused specifically on the experiences of children and young people with rare disease as half of the world’s rare disease sufferers are children. They decided to call it the Rare Youth Project.

“We started working on the a version of the magazine that was not only focused on children with rare disease, but also planned, researched and written by children with rare diseases.” Said Rebecca.

“The kids have chosen their jobs and have set the editorial direction,” said Nicola Miller. “They have chosen the interviews, and not soft topics but big issues and big names. They’ve interviewed people like Scottish First Minster, Nicola Sturgeon. They wanted to do assignments and have meetings, not just to do everything over Skype.”

This version of the magazine will not only be online but will see a print run too as they want to give the children something tangible to be proud of and to enable them to put copies in children’s hospitals and pediatricians thus bringing more people into their community fold. The publication date will be 25th February 2018.

Rebecca Stewart added: “They are really passionate and they want to be heard. They want to have ownership of their voices and of their conditions. Sadly, people often underestimate children’s views.”

The two sisters have no science or publishing backgrounds and have five children between them, run a charity, publish a magazine, write all the content, do all the graphics and layout, do all of the outreach and logistics themselves.

“We didn’t have a business plan when we started it, either of them actually,” stated Nicola Miller, “we just ploughed in, bought a domain and built a website. We do everything, what you see here (gesturing to herself and her sister) is the entirety of both businesses, we’re it.”

“Moving forward, we have to work smarter. We take on a lot and we work very hard but we have very little choice. We are entirely self funded and we will always be a not for profit organisation. Its very important as our community can’t feel safe if they fear we are a corporate entity that may co-opt their story.” Explained Rebecca Stewart. “We would be a very bad prospect for investors because we are not going to change and they are not going to make their money back. We’d love to bring people on board but it's hard to find people willing to work so hard for no money.”

“When our children were born we both decided to be stay at home mums. Stay at home mums do the most important job in the world but society doesn't always recognise that. Said Rebecca.

“What people need to realise is that mums, parents, patients, they are the real experts. They have to become experts, and fast, because their life or their children’s lives depend on it. They don’t get a choice.” Added Nicola Miller. “The culture is changing, patient engagement is a buzzword right now but it must be more than a token gesture.”

Rebecca Stewart went on: “There are problems in this changing culture. There are egos to massage. We can understand that when you have trained very hard in a discipline it must be annoying when your patients have opinions but the patients, their families and carers have got to tread on toes. It's the only way we’ll get the medical working environment to evolve and understand that life with a rare disease or with a rare disease sufferer is full time not just when an appointment comes around.”

Precision Medicine: Advancing Patient Care through Genomic Data

A fundamental shift in medical education is needed in order for doctors and patients to benefit most from advances in precision medicine and information technology. This was the consensus view from the experts at Precision Medicine Leaders’ Summit held in San Diego on the 23rd February.

During a round-table hosted by UK-based clinical genomic analysis software developer Congenica and chaired by Dr. Phil Beales, consultant physician, Professor of Medical and Molecular Genetics at the UCL Institute of Child Health (ICH), and Congenica’s Chief Medical Officer, a range of experts from across industry, government and business discussed some of the most pressing matters raised.

The key messages from the panel were the high need for education and training in all hospitals and clinics in order to keep pace with the shifting face of modern medicine, genomics, bioinformatics, and personalised medicine and to understand the changing needs of practitioners so that research efforts can meet these transitive requirements and the equally evolving role of computational sciences in bioinformatics and interpretation.

Artificial Intelligence in Precision Medicine

The delegates had heard earlier in the day from Atul Butte, PhD, Director of the Institute of Computational Health Sciences at University of California San Francisco, who is working closely with the Chan-Zuckerberg Initiative, on the growing role of computing and A.I. in precision medicine.

“Do you think there really is a place for A.I. in delivering personalised medicine, or is it all just hype?” Asked Dr. Beales.

Rourke Yeakley, “I would say ‘yes’, especially in how it can get rid of bias. One of the things we do in terms of AI is that we bring in research so it’s an integration with clinical information that’s not just based on the patient’s information and thus we get recommended treatment points. Outside of my work in the ER, I also work for an AI company and core to everything we’re trying to do is clinical decision making, specifically trying to understand how we can incorporate genomic data to influence those decisions.”

“You could even eliminate unnecessary tests, a lot of physicians would love to reduce the numbers of tests, but, they worry they may get into trouble for not running these ‘routine’ tests. However, if the AI insisted and its decisions were accepted then malpractice cases would decrease and you would see a reduction in the numbers of tests, a relief to the patient and a burden off the doctor.” Continued Dr. Yeakley.

The human brain is inherently good at recognising big patterns though not always the smaller or more subtle ones. The growths and advances in medicine over the last few decades have been aimed at increasing the amount of data and knowledge to increase the scale of patterns and stratify patients but modern advances in genomics and increasing focuses on rare diseases have brought small deviations and small patterns to the forefront. Whereas even the most experienced specialist may only be able to remember a few hundred patients and their symptoms, a competent A.I. system could bring to the fore patterns and clues from entire datasets with a fraction of the time and resources.

“I like that idea, A.I. is there to help, to support – it is not replacing anyone or anything it's simply helping out and raising the limitations on what’s possible.” Summed up Nick.

Adoption of New Technologies

The delegates went on to discuss adoption of such technologies. For instance adoption of electronic medical records in the UK National Health Service (NHS). “Explaining to the NHS why they need electronic medical records is one thing. Long gone are the days of people being born in Edinburgh and dying in Edinburgh – they need communication between the different NHS systems, especially now that they’re devolved. But, explaining the value in it rather than the cost of it can be another thing.” Said Hilda Mwangi who is a U.S. based, International Business Development Officer for the UK government’s Department for International Trade.

“In the UK, with the 100K genomes project, the only reason it worked as well as it did was because there was a mandate,” responded Nick Lench, Congenica’s Chief Operating Officer.

“But what propels that mandate?” Asked Shikha O’Brien, Congenica’s Chief Business Officer, “it’s money. Unless people see profitability in something or, at least, it equates to value for them, it’s never going to get done. The system has to show that there is monetisation on that value. What the industry needs is validated studies, so, I think it is yet to be demonstrated, this integration of all of this data put together in one seamless way that can benefit the patient. Then, that is when the NHS or organisations like the NHS outside of the UK are going to see value in it.”

“I think part of it has to come from industry and doctors and the growth of private hospitals will drive that. If the private hospitals show profitability and better healthcare because of, for example, connected records – would that push the NHS to do it?” Posited Ms. Mwangi, adding, “So, this is where industry has to step in to engage systems like this for their patients or their parts of the NHS. Sure, the conversation will come back around to cost and value but that is where companies like Congenica can come and get involved in those discussions between physicians and organisations.”

Defining the Transition to Precision Medicine

“The great thing is that we’re the generation that’s defining this transition and we can be the people that define what needs to get taught and how it will get taught. It’s not just genetics, its regulatory, its compliance, it’s the outcomes, for example, how do we handle secondary findings? It’s just so much about amalgamation of all this information.” Stated Shikha O’Brien.

“This is the transition we’re going through right now and it is about education and knowledge around genomics and how it needs to be brought deeper into the standard curriculum. This isn’t a new debate, I attended a conference last year at Stanford and the main topic there was also – ‘how education needs to incorporate more genetics’.” She continued.

“I think that’s where you have to take it into the schools and colleges. You have to educate the kids and then the kids grow up and go on to university and they’re ready for the change, some of them may even be the change. However, if you are already a physician practising primary care what’s the motivation to learn about genomics?” Said Nick Lench. “There are multiple generations involved in this.”

Dr. Beales said: “So, in many ways we’re moving beyond genomics now. We’re here at a precision medicine conference and it's more about looking at longitudinal data on individuals and applying that to their individual health care to make it personalised.”

“But where does this data go?” Asked Shikha, “does it get channelled back into clinical trials? Does it become part of something else either in the wider industry or at the specific hospital? We don’t know but when we do have this kind of data it is often a retrospective analysis. How can we be prospective about such things, especially now that we are in the genomics era? How, as a community or an industry, do we get together and bridge that gap with genomics, pharmacogenomics and pharmaceuticals to then hand that information to a practising physician in a form that can be of direct benefit to their patients or institutions?”

Laura Taylor named in 'Top 50 female leaders of UK life sciences'

Congenica is proud to announce that their Chief Financial Officer, Laura Taylor, ACA, has been recognised as one of the top 50 female leaders in the UK life science sector for the second year running in BioBeat’s annual 50 Movers and Shakers in BioBusiness report.

Laura joined Congenica in 2015 and has played a key role in shaping the strategic direction of the vibrant Sanger Institute spin-out and in promoting its ongoing success. Building upon a successful early career at Deloitte, Laura went on to hold senior finance roles at printhead manufacturer Xaar plc and protein research tool supplier Abcam plc, where she would go on to lead their investor relations activities.

Laura’s passion lies in supporting businesses through periods of rapid growth and innovation by streamlining systems and processes to maintain optimal operational efficiency.

She said: “This recognition comes at the end of a great year for Congenica. We secured over $10m in series B funding, a significant financial milestone for the company and have made progress in new global markets with strategic appointments in the US and China. I’m honoured to be contributing to Congenica’s success in revolutionizing personalized patient care in the field of inherited disease.”

The BioBeat awards were founded by Miranda Weston-Smith, alongside Cambridge Judge Business School Entrepreneurship Centre, to recognise leading women in biotech. It provides a platform for biotech entrepreneurs and leaders to collaborate and innovate.

“The BioBeat Awards are highlighting a new wave of bio entrepreneurship in these turbulent times. The strong message is that thoughtful business strategies combined with superlative science will build sustainable companies to bring better health to people around the world. Collaboration, open innovation as a mindset rather than a focus on IP and pioneering new business models are all part of this toolkit”, said Miranda Weston-Smith.

American Society of Human Genomics Annual Meeting 2017

The American Society of Human Genetics (ASHG) 2017 Annual Meeting took place over five days (17th -21st October) in Orlando, FL. Encompassing all levels and aspects of the industry from pure research to commercial start-ups, scientists from across the globe heard talks, took part in discussions and networked with fellow geneticists. The Society also announced its annual prize winners and introduced a number of leading geneticists from the developing world.

The biggest name of the week was that of Microsoft co-founder and trustee of the Bill & Melinda Gates Foundation, Bill Gates, who spoke with Francis Collins, Director of the US National Institutes of Health, at this year’s Presidential Symposium. The 90 minute discussion took place on the Wednesday night and was the most popular event of the week by far, attracting 32,000 viewers online and most of the 7479 attendees.

Peter C. Scarcheri, PhD and chair of the ASHG 2017 program committee said: “We are excited to engage with Dr. Collins and Mr. Gates on the latest breakthroughs, efforts and challenges in our field as well as explore future opportunities.”

The Gates Foundation has pledged tens of millions of dollars to support genomics and healthcare in the developing. Some of the money has gone directly into projects overseas focused on matters including farming and animal health, epidemic containment and identification such as with the 2014 west Africa ebola outbreak and disease prevention in sub-Saharan Africa.

ASHG also uses its annual meeting to recognise research taking place around the world that will significantly impact the industry. Amongst this year's prize winners were scientists working on new breakthroughs in the use of personal omics in precision and preventative medicine, and the molecular causes behind ciliary disorders, as well as a plethora of other exciting projects.

Dr. Matt Hurles of the Sanger Institute in Cambridge, UK spoke about his pioneering work with the Deciphering Developmental Disorders project (DDD) which recruited 12,000 patients with developmental delay for array comparative genomic hybridisation analysis and exome sequencing. The interpretation and understanding of this data has had far reaching impact in the industry.

Cambridge based clinical genomics analysis company Congenica welcomed speakers from some of the world’s leading genomics markets at their exhibitor symposium: ‘Impacting Clinical Diagnostics Using Rapid and Accurate Whole Exome Analysis’. Each of the talks reflected the global reach, influence and application of their gold standard clinical genomics analysis platform, Sapientia.

Dr. Yuan Yuan Fu, Clinical Scientist at Fuwai Hospital, Beijing has been using Sapientia to analyse the whole exome sequence (WES) data from cardiovascular patients in the Chinese capital. Her presentation focused on two case studies. The first of an 18 year old man who was diagnosed with de novo dilated cardiomyopathy after his WES data was analysed.

The second case study focused on a more complex condition that was initially suspected to be Marfan Syndrome (MFS), due to the patient's phenotypic symptoms and tall stature. They first looked at using aortopathy and multiplex ligation-dependent probe amplification (MPLA) testing for FBN1 and TGFBR2 genes but both of these were negative. WES was applied and Sapientia was used to analyse the results, which discovered a CBS gene mutation with autosomal recessive inheritance and phenotypes similar to MFS, but was in fact the far rarer homocystinuria. Without Sapientia, the diagnostic odyssey to accurately identify this variant would be extremely long - if it was completed at all - using traditional methods.

From the New York Genome Center (one of America’s leading not for profit genomics research institutes), came Dr. Avinash Abhyankar. He told the story of a family who had lost a child at 15 months of age without receiving a diagnosis. Two years on the couple were planning to try for another baby. The only tissue sample available from the child was a dried blood spot, which was used to run WES. The results were analysed with Sapientia and variants prioritised to produce the resulting diagnosis of ASNS Deficiency - a severe neurological disorder that shows its onset in-utero or at birth.

From Britain’s world famous Great Ormond Street Hospital for Children came Senior Clinical Scientist, Dr Natalie Chandler, who works to provide and expand prenatal clinical diagnostic services in a range of rare paediatric specialities. The centre dealt with over 30,000 samples during the 2016-2017 period, in particular non-invasive prenatal diagnosis (NIPD) and fetal exomes. The centre uses Sapientia to provide rapid trio clinical exome sequencing analysis using an exomiser to prioritise variants within the panel and rank how the gene fits with the human phenotype ontology (HPO) terms.

A case study was shown of a patient who presented for a scan at 24 weeks of gestation. Sapientia was used and the variant was identified and classified as clearly pathogenic. The time from referral to a diagnosis of 3M Syndrome was just 12 days.

Over the week attendees heard from many exciting and fascinating speakers, from national projects to niche specialisations and open source data sharing.

MyGene2 caught many people’s attention with what they described as, ‘a web platform for radically open data sharing that’s free, public and searchable to empower undiagnosed patients to leverage and share clinical research sequence data’, in their presentation.

A number of different national programmes were presented, Australia, Japan and Qatar and also breakthroughs in how people share data. The Broad Institute’s Heidi Rehm spoke out about the need to create a comprehensive international data base: “I look forward to a time when we have deciphered all the causes of disorders with a genetic basis and are able to effectively treat, manage and often prevent the morbidity and mortality associated with rare disease. My favourite part of this is watching how quickly we are making a difference to the lives of patients.”

Biotexel’s Genomic Medicine 2017 Conference

Cutting edge science took centre stage at Biotexel’s Genomic Medicine 2017 conference, which was held in Cambridge last week [26th & 27th September] bringing together leading minds from groundbreaking genomic studies and commercial genomic medicine companies.

The two day event, held at the University of Cambridge’s Murray Edwards College, boasted such prestigious speakers as Prof. Carlos Caldos, Prof. Eamonn Maher & Dr Lucy Raymond. Talks focused on emerging methods in genomics, the challenges of large cohort studies, and the new progress towards treating & understanding various cancers, as well as the relative benefits of whole exome sequencing versus whole genome sequencing.

Impact of Genomic Medicine on the Patient Odyssey

Dr. Lucy Raymond, Professor of Medical Genetics and Neurodevelopment at Cambridge University, spoke about the impact of genomic medicine on the patient odyssey, commenting: “In clinical practice, diagnosis is still too slow. We have come a long way. It wasn’t long ago that we were using PCR’s and Sanger Sequencing. The length of time needed has come down drastically but it needs to come down more. Diagnostic yields may still not be as high as we’d like but every success saves costs for the NHS, stress for the parents and, ideally, the life of a child.”

Two other speakers who captured the imaginations of the attendees were, firstly, Dr. Manju Kurian of Great Ormond Street Hospital, who spoke about personalised medicine approaches to childhood neurological disorder, and secondly, Dr. Carlos Caldas, Director of Cambridge Breast Cancer Research Unit, who talked about the progress that his clinic has been able to make by providing genomic profiling.

The Mutational Landscape of Cancer Genomics

Breast cancer in particular was a disease that informed a lot of the talks and debates, with Serena Nik-Zainal of the University of Cambridge and the Sanger Institute, speaking about her lab’s ongoing work to exploit the mutational landscape of cancer genomes for clinical applications.

She said: “The central dogma in a lot of cancer research has been finding the driver mutations. But in cancer things are always mutating, even in health, the human body is always mutating, its natural. We are constantly identifying mutational signatures. Unfortunately we are finding that no two patients have the same drivers and no two tumours have the same signatures.”

“We have been using whole genome sequencing to profile and analyse women with breast cancer and it has been big data that is leading to breakthroughs. We are fine tuning genomic precision medicine.” She added.

The event was a great success with delegates not only fascinated by all of the speakers but with much left to debate at the various networking events.

Dr. James Hadfield, Head of Genomics at Cancer Research UK Cambridge Institute, summed up everyone’s feelings when he said: “We have heard a lot about the great impact what we all do is having on people’s lives and as technology and research move on we will have even more of an impact. Knowing this certainly makes it easy to get out of bed each morning.”

Wellcome Trust big data analytics symposium

Cambridge, UK. - Across the life sciences, statistics and analytics are the crucial elements in understanding and capitalizing on the genomics revolution and in driving forwards personalized medicine. That is the message left with the attendees of the Wellcome Trust Genome Campus symposium on Big Data Analytics for Genetics in Personalized Medicine, on Saturday 9th September.

Clinicians, doctors, researchers and students gathered at the Francis Crick Auditorium in the bright, early autumn sun to await the day’s talks by some prominent experts from world renowned institutions.

The presentation that created the most buzz on the day was a rallying call for the need to crowd-source and globally collaborate on variant curation from Broad Institute Member, Dr. Heidi Rehm, who spoke about standards and approaches to support genomic variant interpretation. This has recently become tragically topical as, in the US, there has been the first lawsuit over a misdiagnosed variant.

Dr. Rehm told the audience: “We are seeking to redefine clinical relevance and disease validity clarification through a semi-quantitative system, aggregating clinical evidence and giving variants a validity score. At the moment, too many genes which are reported as related don’t have enough supporting information. What we do have is a huge number of experts from whom we can essentially crowdsource this. The database is open to the public and follows all ACMG rules and uses industry accepted ideas and terminology. Submissions have to show how they came to their conclusions and then we work as a community to resolve conflicts and discordance. In fact, so far, we’ve resolved 72% of the 300 conflicting variants we’ve faced so far. Systematically we can reassess outliers, support clinicians and affect patients.”

The next came from University of Southern California’s Associate Professor in the Department for Preventative Medicine, Dr. Kimberly Siegmund who spoke about using statistical approaches to investigate changes in the mutational processes during the growth and development of a cancer or tumour.

She said: “We know tumours share ancestry, that they all have a tumour initiating event. We can learn about the mutation process and sequence tumours to build a catalogue from which we can then infer patterns and draw contextual data from neighbouring bases. This gives us multinominal probability.”

Dr Seigmund’s lab undertakes multi region sampling and whole exome sequencing with a minimum of three runs to understand the diseases trunk and branch mutations and try to glean any de novo mutations contained within to add to the catalogue using a descriptive framework.

Underpinning these ideas was a phrase from the day’s first speaker, Dr. Chris Spencer, head of innovation at Genomics PLC who spoke generally on improving healthcare with genomics. He said: “Genetics is the best chance in a generation to make a major shift to better healthcare, at the very least, to improve the efficiency of the doctor’s toolbox. Over the next 10 years, as a global industry, we will be sequencing millions if not billions of genomes but unless we make use of that data it will be useless. Frankly, even if all the sequencing machines in the world blew up this afternoon, we would still have enough data to be working on for the next 50 years!”

After the intermission, things took a turn to the technical. First, attendees heard from Dr. George Davy Smith, Professor of Clinical Epidemiology at the University of Bristol, UK, who spoke about Mendelian randomisation in a data rich environment.

Dr. Davy Smith utilized a number of formulae and graphs focusing on utilising resources such as the UK Biobank to more deeply understand factors of disease progression and how pleiotropy can influence outcomes but that variants may still be data derived.

The last speaker of the day was Dr. Hae Kyung Im, Assistant Professor of Genetic Medicine at the University of Chicago, USA, who spoke about integrating GWAS, omics and electronic medical records to dissect disease biology.

“Recent progress has allowed us to generate huge amounts of HTS data and to be able to interpret this data. At Chicago we are ambitious and we want to characterise the phenotypic consequence of all human genes.” She said.

Dr. Im went on to talk about her new project, The Human Knockout Project, which is a systematic effort to understand the disruption of any given genes and to learn more about why some drugs do not work on some groups.

The day overall was a great success. Complemented by the lovely weather, the conducive staff and inspiring exhibitions attendees and speakers alike enjoyed a stimulating and interesting range of discussions and debates.

Genomics revolutionising opthalmology

One of Britain's leading experts in ophthalmology and genomics has been named in the Queen’s birthday honours list for his services to these disciplines.

Prof. Graeme Black of the Central Manchester University Hospitals NHS Foundation Trust has been honoured with an OBE (Order of the British Empire) - one of the highest civil awards in the UK. We spoke to Prof. Black about the OBE and looked at some of the reasons why he has received such a prestigious award:

“Inherited ophthalmic disorders and particularly inherited retinal dystrophies have served as a paradigm for developing molecular analyses of genetically heterogenous conditions. We have a long and successful record of disease gene identification and mutation detection using a combination of genomic approaches. Consequently our molecular diagnostics services have much higher success rates which represents a remarkable transformation in efficacy over the past three to five years.” Said Prof. Black.

Professor Black’s strategic leadership has been integral to Manchester becoming one of the world’s leading centres for inherited ophthalmic diseases. The team, which he has built, represents one of the brightest and best multidisciplinary clinical services in the UK and has worked extensively to integrate genetic testing, bioinformatics and next generation sequencing (NGS) into general clinical practices.

Prof. Black said: “We hear a lot about translational medicine, a lot about the ability of biomedical science to improve healthcare. I believe that genomic medicine is one of the areas that will be at the forefront of it all. Those technical changes are being translated into medical practice and implemented as we speak. Right now, here in Manchester, we’ve seen diagnostic rates improved from 5% to 75% for ophthalmology.”

Rare diseases affect as many as 3.9 million people in the UK1 alone and, of the eye diseases, 80% of these are genetic in origin1. In fact, it goes deeper: 60% of all cases of blindness amongst children are hereditary and 40% of all ocular misalignments manifest in those with a family history of eye diseases1. Efforts are underway at the moment in Manchester and around the world to identify all the genes in question.

The eye itself is an incredibly complex organ and this is mirrored in its genetic make up, as at least 90% of all of the genes in the human genome are expressed in one or more of the eye’s many tissues.

Prof. Black joined CMFT in 1995 as a Wellcome Trust Clinician-Scientist Fellow. His recent royal reward is a recognition of his foresight in the care potential that genomics can unlock. The disease prevention, prediction and treatment possibilities that have come with it led to him overhauling the infrastructure, investment and research at CMFT in order to improve the diagnosis, management and treatment of inherited genetic visual disorders.

During his 22 years at the Trust, Prof. Black has championed the use of genomic information in clinical care, and he has been able to redefine the delivery of personalised care for patients with a variety of inherited eye disorders throughout the UK.

Prof. Black believes that improvements in diagnosis will drive improvements in treatment and that these changes will be felt by all patients. An accurate diagnosis underpins everything done and attempted in medicine. The difference that genomics makes is that, particularly with cancers, heart disease or conditions like hypercholesterolemia, those early diagnoses save lives.

“The rate of change has been high and there’s no question that it's accelerating in pace with the amount of sequencing we generate.” Prof. Black went on, “our ability to deploy this data and use it to fight serious diseases is getting better and better. Genomic knowledge is expanding and personalised medicine is becoming a reality for oncology, pediatrics and adult medicine. I have no doubt that this is the future of medicine.”

Though NGS isn’t cheap, it is more cost effective than the raft of invasive tests, retests and clinical decision meetings that can take place over a lengthy diagnostic odyssey, and that is not taking into account the stress generated for the patients and their loved ones. This is one of the biggest strengths of genomics in such fields, the ability to eliminate much of that diagnostic odyssey, especially in rare diseases where it can commonly take months if not years to be accurately diagnosed and treated. For example, the average diagnostic odyssey for a UK patient is 7.3 clinicians and 4.8 years to reach diagnosis but with new genome sequencing & analysis technologies it can be as little as 1 clinician and just 5 days.

These methods aren’t without their own complications. Some of which are as simple as the growing need for expertise amongst clinicians, doctors and consultants to keep pace with the technology and developing methods. Some are in security, such as the need for privacy and consent due to potentially damaging unexpected findings presented in the results and the implications of hereditary disease on the other family members - all of which are further heightened by the deeper legal complexities surrounding children.

At the core of Prof. Black’s work in genomics have been ground-breaking advances in both sequencing technologies and in clinical genetics analytics platforms, which have enabled the labs to go from offering testing in around 10% of cases to testing almost universally. This wasn’t possible before, as the cost and time requirements were simply too high to be practical, but technological breakthroughs have empowered clinicians to get results much faster and more accurately. The shift in aetiology due to this has been enormous.

“As fast as the technology moves,” Prof. Black added, “we must be mindful that broadening access to genetic testing and counselling will be crucial to realizing the benefits of personalized healthcare and must be supported by a clear understanding of the necessity in standardizing genomic care.”

Software and associated databases also enable clinicians to provide lists of potentially disease-causing variants that can be assigned pathogenicity by users and can be added to at any time creating a living and ever-growing frame of reference from which clinicians and doctors can save even more lives in the future.

What is America? Part 2

From left: Fayyaz, 17, Sarah, 18 and John, 18 ,all from Los Angeles, Ca.

From left: Fayyaz, 17, Sarah, 18 and John, 18 ,all from Los Angeles, Ca.

Fayyaz – “What is America? Greedy. That’s the first thing that comes to mind. We have so much here and everybody could have enough but people are too greedy. Obviously the ones everyone talks about are the 1% but you can see the same attitude in all aspects of society. Everyone wants more, to get richer, to have the latest phone, biggest car – people think that these things give them worth. What else? Proud. America is so proud of itself. I know that outside of America people think its arrogance but I think that its just pride and they have a lot to be proud of.”

 

Sarah – “Oh my god! Fayyaz was so deep, I was going to say hotdogs and hamburgers! Ok, I think the most important thing is that we’re the most democratic nation on earth. Because we’re a young country we don’t have all the baggage that those old European countries do and we have the constitution and stuff. Like, where else would you get a black president? The next thing I’d choose to describe it would be quality. Like, everything you get here is good. Like, the food and the clothes and stuff, here, we get the best. What else? Ok, football! Go Bears!”

 

John – “America is a great nation outright. I know we get criticized but when you are at the top people do scrutinize you more. We have had the biggest impact of the world since Rome and I think we will continue to do. America suffers though because there is too much corruption at the top. Too few people involved in the direction of the federal and national stuff like military and business and politics and stuff. I think this can be exacerbated by the fact that we’re sort of overzealous as a society. It’s so hard here for anyone to have a reasoned debate about any issue without people taking it to an extreme. Like gay marriage or teaching evolution. I think within that is a sign that maybe we are past our prime now. You know, too many of the old generation are still running stuff and they have a different agenda than today’s young people because we’ve grown up in different worlds. The three of us probably couldn’t even have sat together 50 years ago. One of the problems for me though is that the media and politicians keep talking about things which should be people’s rights as if they’re privileges. Like the laws they’re passing to control the Occupy movement which are against 4th amendment or SOPA.”

 

 

 

 

What is America? Part 1

It's a curious question and one which is made all the more pertinent by the hegemony of American films, music, tv, personalities which often dominate the world's mainstream media.

 

But what about beyond that? How do Americans see themselves and their country? As I've spent more and more time here I wondered myself so I decided to start asking people.

From left: Savannah, 18 from Los Alimos, Ca. Nicola, 17, from New York. Victoria, 17, from Fort Lauderdale, Fl.

From left: Savannah, 18 from Los Alimos, Ca. Nicola, 17, from New York. Victoria, 17, from Fort Lauderdale, Fl.

Savannah - "America is fat. We have a real problem with people's diets and attitudes to food and health, in fact I think that people's diets are more of an issue than alcohol and stuff. We are distracted as well. Our media don't really tell us what's going on in the world so people tend to think insularly. But there are contradictions too because I think we are also much more athletic than other nations, American guys all do lots of sports and join teams and stuff. That's why so many of them are big strong guys, not like in Europe or somewhere. We are also kind of socially obsessed. All the way through school and college we have to join these teams and go to rallies and cheer and join in. You always have to join in. We are kind of pushed and pulled and molded to be more like everybody else, you know, more socially acceptable."

 

Nicola - "What is America? Jail, police, cameras. I mean, after the whole 9/11 thing they passed all these laws like the Patriot Act and now you've got these Occupy guys and they want to make laws for them. They are against the Bill of Rights or the Constitution or whatever but Congress let them. Then you have these big corporations getting money off of the Iraq War and they're all headed by ex-politicians but everyone is ignorant of what's going on. I guess that's my next point then, ignorant. But I think that most Americans would want to know, I think its a stereotype by the Brits or someone that most Americans are rednecks living in trailers. I don't think that's the case, people ae smart people but they don't get properly informed. Last of all I would have to say rich. What passes as the middle class in America would probably pass as the upper class in most other countries in the world. Our cars, our houses, all the meat and gadgets. We live well and I hate it when you see people complaining that their life is so bad here. I mean, like, seriously?"

 

Victoria - "I don't agree with Nicola, I think that we are super free here. In America we have more liberties than anywhere else in the world and I think we're much more expressive than other cultures which is why American movies and stuff are so popular all over the world. On a negative point, I think that we can be too divisive. I mean, like politics, in an election we don't really hear about economy or stuff but just get the same debates about abortion or gun control or about teaching evolution or something. I think that people use these debates to distract people from the real issues or from looking to deeply about what they have said before. Like with WMD's, when we said Saddam had them and everyone else said he didn't so we went to Iraq and he didn't but everyone started saying 'we had to topple a dictator' and the original reason gets forgotten. Oh, and we have too many fat people."

 

The London Stone

Around the height of your knees, inauspiciously tucked into the wall of the Bank of China on Cannon Street, is a small bay window with white painted iron curves decorating and protecting the London Stone.

About two feet high and with a dull groove upon its top it has occupied its spot since, some believe, the days of Romans. For many centuries it was claimed to be ‘the stone of Brutus’. Brutus of the dagger plunging fame, who brought it to the city as a deity to protect the city.

“So long as the stone of Brutus is safe,” ran one proverb. “So long shall London flourish.”

The name ‘London Stone’ then appears in a book belonging to Ethlestone, and early tenth century king of the West Saxons in which certain lands and rents owned and owed were described as; ‘to lie near unto the London stone’.

It remained in the same spot all these centuries, this single block of oolite a perishable rock which could not have survived intact all this time without a charmed life.

In 1742 it was moved from its seat in the middle of Cannon Street, a spot which the ‘Victorian County History’ believed marked the exact centre of the old city, and built into the fabric of St Swithin’s Church. There it remained until the church’s destruction at the hands of a Nazi bomb in 1941. The stone remained intact.

There have been lengthy debates surrounding its religious, political and historical importance. William Blake believed it marked the site of druid executions and sacrifices. Some believe it was a token of civil assembly connected with law making or the repayments of debts.

Others have claimed it to be nothing more than a roman milestone though many, including Christopher Wren, have argued against this theory claiming it to be too large for such a purpose.

When the rebel Jack Cade stormed the city in 1450 he and his followers made their way to the stone where upon he touched it with his sword and proclaimed himself, ‘lord of the city’. Even the first official mayor of London in the late twelfth century was Henry Fitz-Ailwin de Londonestone.

Now behind soot blackened glass and wrought iron armoured with a dozen decades of paint it sits. Silent and disregarded by the knees and feet, ankles and shoes that pass it every day. As it broods protectively in its timeless silence and benevolence.

Copyright 2006

Once upon a Kilvackey Road

“We don’t blame you.” That was all they said, those two tired dignified eyes staring at me with stoical pity across that blank and faceless table in that blank and faceless room of this blank and faceless hospital. “We don’t blame you.” I don’t know what else I expected to hear. I don’t know what else I wanted to hear. I don’t think there was anything else I needed to hear.

I had sat for a couple of moments facing this brave, slight woman in her early fifties, alone. Some strings of silver laced into her tired brown hair, I wondered if they had been there before all this? We sat there in silence, she spoke the only sentence. We felt no distance, no embarrassment or discomfort in each others company. Once more she played the rock, this time for me. She spoke that sentence, the silence descended again, cradling us and finally…finally I cried.

She had sat with me and watched me and maybe she felt a little less isolated. Maybe I gave a face to all of this, one that was different from any of the officialdom she had faced before. One that was vulnerable and lost. One that could prove her grief was not only a figment of her family’s existence but was tangible in someone else’s world. Maybe she felt reassured, maybe she didn’t.

I cried. I opened and it came flooding out. Afterwards, after the tears had stopped and my chest ached from the exertion. I could feel my scar beneath my shirt, four inches across and almost two deep. I was lucky it didn’t burn to the bones the doctors told me. I looked up with my puffy bloodshot eyes and things felt a little bit different. Things were clearer, better defined, in conception and perception, to me at least, they had changed. It was as though the tears had helped to wash away some emotional cataract. Nothing had really changed, nothing could be changed, a will always be a, but it felt a little clearer. It felt like a step forward. A step away.

As I stood, that last afternoon in the hospital, starring blankly out of my window towards the green lawns and grey tarmac, I thought again about those eyes, about what they carried. I compared them to the other set of eyes which had brought us both here. Eyes I’d never seen. The weight of the world was in hers and I wondered what she had left. At least she had her grief, what did I have? I noticed absent mindedly that my hand was at my chest. I looked down at the deep purple of the charred flesh, my flesh, and thought I felt it tingle, begin to sting. I put the thought from my mind. I didn’t want to feel it, didn’t want to feel it ever again but it would always be there. That is what I have; my scar.

 

It was to be my first official duty after completing basic training. I was nineteen years old, it was the summer of 1979 and I was to drive a lorry load of excess supplies and one excess Sergeant to Belfast Barracks. The barracks were less than fifteen miles from the docks, it would take no time at all, that’s what the Sergeant told me.

“We’ll be in and out in a few hours lad, don’t worry.” But I worried. “It’s a bloody nasty place, they’ll hate you because of nothing more than your accent and your uniform. They don’t care about who you are, they’ll just hate you. Women, men, kids. We’ll have no problems though lad, twenty minutes on the road, an hour unloading and then straight back to the ferry and off that bloody island. That bloody Ireland, you get it lad? No? Don’t worry lad, you’ll be the star of the mess tonight.”

As I slapped a clip of rubber bullets into my weapon, huddled on the road by the curb and the destroyed wheel of the three tonne lorry. Holding the Sergeant in my lap as he bled slowly and breathed slower wondering where the next bullet would come from I realised that those words had been as much to comfort him as they had been to comfort me.

We had disembarked the ferry at Belfast docks without incident. We received a message that our escort of an armoured land rover had been delayed due to mechanical problems and had still not set off to meet us. We were an unscheduled transport of a single truck carrying only forty boxes of blankets and cutlery down one road for fifteen miles. The area had been silent for days previous and we decided we could make the short trip quickly and before our presence was known. We set off down a road I will never forget. A name which will always lie heavy on my mind at it’s every utterance. One that will burn behind my brow like brewing tears. Kilvackey Road.

 

The mood in our cab was fairly light hearted, at least from the Sergeant’s side, it was a bright sunny lunchtime and though I was still afraid, more deeply nervous than afraid, I was starting to believe the Sergeant that we may be back in England by teatime.

We drove past bungalows and pubs, a small corner shop and a group of kids playing football. Each face we passed paused and turned towards us. They starred, starred right into my eyes with jaws set and lids narrowed and gave me a look and a sense like I have never received before and never hope to again. I swallowed the lump in my throat and gripped the steering wheel tightly with shaking, sweating hands. The mood in the cab had changed.

Four and a half minutes into my first duty in an active and operational theatre, driving along that empty afternoon road we approached a low rise block of flats and a second group of loitering youths a noise rang out. An indefinite sound to my ears. I didn’t recognise it at first, I didn’t have time to. The lorry jerked violently like a horse trying to bolt and throw its rider, leaping up from the road and throwing back its head, canvass mane curling in the air. It hit the tarmac again and lurched wildly to the left and I stamped on the brakes moments before crashing into the pruned roses of a suburban front garden.

The Sergeant looked at me about to speak. I wanted him to say something, anything, something benign. “Damned awful time for a puncture.” Or. “Did you not see that brick in the road lad, be a bit more careful will you?”

He didn’t get an opportunity to speak, to say anything. I don’t think I heard the sound though I probably did. The passenger side of the windscreen exploded. Drops of laminated glass scattering and leaping like escaping diamonds. Not all diamonds, some were rubies. Like a fool I covered my eyes.

I opened them almost instantly, training overriding natural instincts. The Sergeant was pale and sweating, his right hand held to his neck. The windscreen had been pierced too, either on exit or another entry I hadn’t noticed, and on what remained the sun shone through a spray of crimson casting a red shadow across us both in macabre illumination.

I leaned over him, throwing open the door and scrambling over him. I was speaking though I still can not remember what I was saying. I rolled him up and onto me as I dropped out of the door and onto the pavement besides the garden wall hoping the bulk of the great green steel truck would afford us some protection. I remember my eyes scanning my surroundings for some sign of danger, something to be suspicious of, something tangible to fear but everything was so normal and everyday. Houses, curtains in front rooms and bedrooms, gardens with flowers and shrubberies. Where were the charging, ski mask clad men in black I was trained to face? To aim at and fight? Such an imaging had filled me with fear throughout the months of my training and the weeks of waiting that followed but now, surrounded by suburban pleasantries, they were infinitely more preferable to this no-mans land of normality.

Another shot came, every cell in my body flinched in anticipation of the impact but I didn’t stop moving. I had to get to cover, get the Sergeant to cover. The impact came, not as I’d expected to me, though I felt its reverberations. The Sergeant let out a heavy breath and with it I realised he had been hit again. It felt surreal, he didn’t shout or scream, writhe or cry. He just gave this great heavy sigh and I held him tighter as the camouflage of his trouser leg grew darker beneath the knee.

We sat huddled on the ground, I prayed we were out of the gun sight though the shot had proved that we weren’t. For all I knew we could have rolled right into it though in hindsight I was a fool to think they wouldn’t just move if they lost their shot. I sat shaking on the warm concrete of a suburban street, cold sweat on pallid skin, on a sunny afternoon hiding from a sniper who could be anywhere. Invisible.

I smacked a clip of rubber bullets into my weapon with the heel of my hand, though I hadn’t fired a single shot from the one I removed, and felt a moments guilt for wishing they were real ones as I clutched it closely to me as the Sergeant lay in my lap, his breath coming in slow deliberate heavy gasps. I wondered if he had been wounded before? How long had he been in the army? Had he been to war before? Were we at war now? But most of all I wanted to ask him; what do I do now?

 

We sat for agonising minutes waiting for the next bullet. The next hollow crack of a distant rifle. The jack was just beside my right shoulder in the passenger side foot well. Training tells you to grab it, change the wheel and get the hell out of danger. Easier said than done with a wounded man in your arms, and death nearby, all while you clutch your rifle which isn’t even filled with real bullets, in fragile cover next to someone’s prize roses.

We sat for more agonising minutes. I realise now that I was frozen. I couldn’t have moved if I tried. I was shaking, petrified, hunted, cornered, a panicking child playing at being a man in a game he now realised he never knew the rules of, listening to the laboured breaths of a man who I had met only hours earlier. The first ten minutes of active duty.

Crash! The sound of one of the trucks headlights shattering, tiny fragments of glass and mirror dancing on the road. I tightened, tensed, felt like I shrank. Another noise, a hollow clang of denting metal. Voices. Laughter. Suddenly I realised these weren’t bullets. Dung! I peered cautiously beneath the door to see half a red brick dropping to the concrete after hitting the radiator grill. I could see feet too.

Small trainer clad feet. For a second relief rushed over me. Up and through me. I wanted to stand up, call them over. Get help, go home. Smash! I was showered with glass again. A brick had come through the passenger door window. They were trying to hit me with them! They were laughing! Kids!

I couldn’t comprehend the situation. The Sergeant just kept breathing in his slow, deep deliberate way. Meditative almost in its rhythm. I shuffled him round and half propped him against, half tucked him under the steps of the truck. I peered around again for another look. They were gathered around something.

Why hadn’t anyone done anything? Why were there no sirens? I looked at the house, at the windows. Did the curtain move? What are the kids doing? Moving, excited. Where were their parents? Did they not know we were hurt down here? Did they know we were here? Should I call out to them?

One began walking forwards. He had seen me. I clutched my rifle. Rubber bullets can still kill you if they hit you in the right place. Even if they don’t they still pack an incredible punch. Just a bullet that doesn’t break the skin.

He had something in his hand. How do you shoot a child? Why would you need to? “You fucking English bastards!” He shouted. And he let it fly, a small glass bottle with a rag in the top. My stomach lurched. I wanted to run but I was frozen. I wanted to scream but my mouth and throat had dried to sand paper. I wanted to shut my eyes but I couldn’t look away. I didn’t want to burn.

The bottle hit the ground with a slight plink and skidded across the concrete. My jaw dropped, it hadn’t smashed, it hadn’t exploded. Two feet away from me and it had simply skidded to a harmless halt. I was exalted by this reprieve and scurried forwards. I grabbed the bottle, square and sturdy and threw it away, I had to get it away, I had got a chance to save us both before it cracked or the flames on the short rag crept inside its neck.

It was at this moment, exposed but saved. There was a soundless thunder strike. Whiteness everywhere. Rushing noises filled my ears like I was under the waves of a stormy sea. I stumbled back dropping my rifle. Clawing at my chest. Something was coming away beneath my fingers. Something was trying to burrow into my chest I could feel it.

I was unaware of the other noise building behind the rush, my ears still ringing, my eyes still filled with white. The shouts and voices. Lots of voices. There was another rush. Freezing, choking this time. Blowing the things from my chest and filling my nose and mouth suffocating stenches and chemicals. I felt my body heave and wretch. I passed out.

 

I came round a week later in a different world. A world of white linen and crisp folds. A world of women with gentle faces and sad smiles. On the second day they told me a man was there to see me they propped up my pillows and told me to wait for him. Where was I going to go? I didn’t even really know where I was.

He arrived dressed in khaki with his hat beneath his arm. His moustache made him seen like he’d stepped from an old war movie but there was to be no, ‘what what old chap?’

He told me what had happened with a deliberateness which served to tell me that he wasn’t going to repeat himself. I had been hit by a phosphorus bomb. The kids had been a diversion set to draw me out less a get a shot off at my, suspected, lone attacker. The sergeant had survived and was recovering well.

I would be scarred for life and was to be discharged from the army upon my leaving the hospital. The petrol bomb I had thrown away had hit one of the kids. Burnt him on the pavement outside of his home. He had died two days ago in the intensive care unit of the same hospital I was in. It had been a major incident but they were succeeding in playing it down, keeping it quiet.

As he opened the door to leave he paused and turned back towards me. The boy’s family wanted to see me, well the mother at least, to talk to me when I was well enough. It wouldn’t be more than a couple of days, he said, apparently I was healing well.

 

Copyright 2007

 

China's Bulldozer Gentrification

Four days ago this area had been a bustling and vibrant community. Within an hour of taking this image I would be in the hands of the Chinese police, struggling to keep my camera in my hands and the rest of me out of their van.

 

I had wandered through the tight alleys and courtyards of the Hutong style homes caught in their overlapping sounds and smells. It was a small area tucked in between a new overpass and supermarket on two sides and railway lines on the other. It was a working class neighbourhood, it was late afternoon and the population was exclusively elderly and children, all of the mothers and fathers away. Most of the men who would return later that evening in their blue and orange uniforms of the railway station and freight yards, and fill the tables that would appear on the wider streets, surrounding the various street food vendors as they work from portable kitchens either built into or towed by their bikes. There is a wholesale fruit and vegetable market nearby which attracts the farmers from the outlying villages who, at the weekend, will drive slowly through selling the last of their wares at a cheap rate in this and neighboring districts. In a few places they stop and drop off bigger bags at one house. “That lady will take it to the old and the sick, those who do not have children to care for them.” One of the street vendors explained.

Hutongs had been the predominant form of housing in China for centuries, if not millennia, and were prevalent in every major conurbation. One Hutong in Beijing, Sanmiao Jie, is claimed to be over 900 years old. Though surviving older hutongs are extremely rare, the majority date from the first half of the 20th century. As the Qing Court and its bureaucracy disintegrated the previously carefully planned hutongs began to spread rapidly and haphazardly. The following governments of Sun Yat Sen or Chiang Kai Shek made no attempts to monitor or regulate the situation or the materials being used which meant large portions of this new housing was sub-standard.

The exceptions were the foreign controlled treaty ports and cities such as this one. The majority of Jinan and Shandong’s infrastructure and industry was built by the Germans in the years before the First World War. They built railways, steel foundries, coal mines and harbours, all to their stereotypical high standards and though they were very much second class citizens under an unjust system, the Chinese workers here and in other European controlled areas earned more and lived better than all other parts of the country.

I had come back for greasy potato fritters and cheap beer served in plastic bags but all was but rubble. The open space at first seemed big then I remembered how it had sounded and it suddenly seemed such a small plot of land to have such a sense of community. I walked unsteadily over piles of red bricks and white plaster. There were belongings amongst the rubble, clothes, kitchen utensils, toys, a PLA dress uniform hat, some boxing gloves.

 

The destruction of the Hutongs has always been on the Communist Party’s agenda but the reasons have changed drastically. In the early years of the Party and Mao’s rule most of the demolitions were to directly improve conditions for the people. Under the supervision of Prime Minister Liu Shao Qi living areas were inspected and altered to whatever the local water supply, sewage system, or simple population density could support. It was the urban side of their crucial ‘land reform policy’ which prevented private ownership of land and began the party’s first major land grab. During the chaos of the Great Leap Forward and the Cultural Revolution things went in the opposite direction and families were heaped in to the hutongs, one per room. The residents had no choice over who would live with them and homes which previously held four or five now held up to 20. Many people ‘informed’ on their new neighbours as counter-revolutionaries for any perceived slight, such was their anger at the situation and the climate of terror was fuelled further. The urban version of the collectivism forced on the countryside. The hutongs began to fall as part of Mao’s ‘Campaign against the four olds’ and others to make way for industrial plants and factories in the heart of the cities to create what Mao called ‘a beautiful skyline of chimneys’.

The area looked deserted which is incredibly rare in China. There was no traffic on the road as there was no longer anything for it to take you to but sites like this were usually swarming with people. Usually migrant workers from the poorest parts of the country who work in shifts, day and night to break down the buildings and organize and clear the rubble. They wear no protective clothing, gloves, goggles or even boots. Their tools too are generally no more advanced than pickaxes and sledgehammers. Also missing are the small triangular flags or various colours, more commonly called bunting, which they use in China to demarcate dangerous construction sites.

The largest and most insidious land grabs have happened since 2006. There was a sea-change inside the Communist Party when the announcement came of the 2008 Olympics. They haggled and bartered to have the start date moved to the 8th August 2008 as this date 8-8-8 is especially auspicious in Chinese culture with 8 meaning ‘prosperity’ accentuated to an unprecedented degree by the alignment of the day, month and year.

I saw a man squatting in the rubble nearby. “Hello.” I called.

His flinch was visible from my ten feet away but he relaxed for a moment when he saw my foreign face. Then he sprang into life. I had been walking towards him and was only a foot away now. His voice was fast and frantic and thick with the local dialect. I tried to tell him I couldn’t understand but he cut me off pushing my right hand with my camera in it up to my face. “Zhe ge! Zhe ge! Zhe ge!” (This! This! This!) He shouted, pointing around. I started taking pictures and he began scrabbling in the rubble looking for something. He came up a few moments later with a piece of chalk and wrote on the wall:

“Si you cai chan, shou fa lu bao hu; zheng fu bu men bu gu min heng, qiang xing chai qian.”

“Private properties are protected by law; the government disregards the people’s will, tears down their houses and forces them to move.”

The man was middle aged yet it has hard to tell exactly. His skin was dark and his hands and grip were like stone, so it is fair to guess that he worked outside. His eyes were doing cartwheels in his head and then suddenly he seemed to gain focus. “My home,” he said in slow, heavily accented English. “Wo xie, ni zha xiang, zai zhao ren fan yi. Kuai dian er.” (I’ll write it down, you take pictures and find someone to translate later. Hurry up!) He spoke tersely and with deliberate tones to make it easy for me. I took pictures of places I recognised. The house with the tree in the courtyard, the house that was cooking spicy soup, the dress shop with its naked mannequins.

 

The Chinese people can never legally own their own home or property. The structure of the property law in China has at its core State ownership of all land within the country. Leases are then taken on the property, the maximum duration of which is 70 years at this time the land reverts back to the government. This has denied people one of the most basic forms of human security: The knowledge that you and your family will always have a home.

He dashed up to me again, climbing on his bike as he spoke. Three large, dusty carrier bags were now tied to his bike rack with string. I held out my hand to offer a handshake. “Ni sha a?” (Are you stupid?) He slapped my hand away and pointing up to nearby flats said: “Yao shi you ren kan jian le, ken ding hui da 110. Zou! Kuai! Ben si le!” (If someone saw, he’ll definitely call the police. Go! Fast! Uh, deathly stupid!)

Before the Communist government took over in 1949 the Chinese had been able to own property and pass it down in the family, a tradition in keeping with Confucianism’s fealty. The government would go on to first seize any property owned by landlords, then the bourgeoisie (merchants and intelligentsia) then peasants through collectivization and finally industrialists and business owners who were seen to be ‘taking the capitalist road’. By the end of Mao’s reign of terror the country had become 90% agrarian and most people lived at a standard last seen in the west at the end of the 18th century.

He pedaled off and I started walking. I switched the memory card in my camera and it went with the note into my pants.

I heard the van before I saw it, heard the engine driving fast and closing on the blind corner which was my only safety. It was rubble and open space all around but there was a structure off to the edge still standing, at least three walls were, and I made for it. As I crossed the threshold it became apparent why this building hadn’t been pulled down too. It had been used as a toilet by the workers. The evidence was everywhere. The van screeched to a halt and I made a valiant effort of walking casually off. Sadly the van simply rolled slowly alongside me and a fat sweating man in the passenger seat chirpily asked: “Ni qu na er?” (Where are you going?) They pulled slightly ahead of me, the door opened blocking my path and that was that.

There were two police men in the van. The passenger who had spoken to me stood, bulkily smiling while the driver climbed out of the otherside. He was a small, skinny man who walked with his head and shoulders thrust forward and the look of an angry teenager on his face. Immediately he began shouting and pointing his finger at me. I raised an eyebrow to the fatter one.

“Hui shuo zhong wen ma?” (Do you speak Chinese?) He asked.

“Yi dian er,” (A bit) I replied, “qing shuo man yi dian er.” (but please speak slowly.)

“Gan ma ne?” (What are you doing?)

“Zou yi zou, kan yi kan.Wo gang lai, guang yi guang.” (Walky walk, looky look. I am new here so I like to wander.)

“Ni wei shen me zhao xiang?” (Why did you take pictures of this?) He extended his arm to the rubble. The other man walked away from us.

“Jiu kan yi kan.” (I didn’t, just looky look.)

“You ren kan jian ni le! Na ge ren gen ni shuo shen me le?” (You were seen. What did the man tell you?)

“Ta shuo jinanhua. Wo ting bu dong. Wo jue de ta hen sheng qi. Ta chao wo han.” (He spoke Jinanhua (local dialect). I couldn’t understand him. I think he was angry. He shouted at me.”

The other man called over from the ruins, he had clearly found the chalk message.

There was a spell of silence. The fat man said something I didn’t understand. “Xiao xin, che”. (Caution, cars) He stated simply, though I had seen no other traffic all afternoon. The skinny man was standing by an old shop front. It had no first floor but a metal roller door was still in place. He beckoned us over. “Re si le,” (Hot as death) said the fat man. “Jin lai.” (Inside)

“No.” The words came out strangely, I was clearly more scared than I’d realized. I squeezed my camera to stop my hands from shaking. The fat man was grinning at me. I said it again, this time it came out like a bark. “No!”

There was a pause. “Jin lai!” (Come on!) He said taking hold of my arm. His grip was spongey and I was easily able to twist my wrist and push him away.

“No!” I barked again.

“Xiang ji gei wo!” (Camera, give me!)

I held raised it slightly and brought up the image review screen for him to see. He wrapped a sweaty hand around it but the strap was wound four times about my wrist so again I broke his grip. His hand had left a damp outline on the black plastic.

I was then suddenly off balance. The skinny man had come up behind me and was trying to pull me by my rucksack. I skipped backwards, removing the resistance and causing him to stumble.

“Hu zhao na lai!” (Passport, here!) Said the fat man.

“No.”

The skinny one was behind me again and he plucked my notebook from my back pocket and tossed it to the fatman. He opened it and dropped it in the dust at his feet. “You qian ma? Fa kuan.” (How much money do you have? There is a fine.)

“Mei you.” (None.)

“Hahaha… shang che.” (Get in the van.)

“No.”

“Dao na ge lou li qu.” (Get in the building.)

“No.”

They had gradually worked me back to the edge of the rubble and off the road. I was in trouble. The skinny man was grabbing at my bag, the fat one at my camera. Somehow the skinny one managed to retrieve my phone from my pocket and deftly popped the back off and battery out before dropping it too.

The skinny man was shouting again, his finger jabbing at my chest. His words were fast and spat at me. The only ones I recognized were curses. The fat one just laughed. “Xiang ji, ding fa kuan!” (Camera, is the fine!)

None of us heard the car pull up but we heard the door slam. Everything stopped. The fat man suddenly looked serious, the skinny man physically jumped and I took the chance to move out into the road again. The car was an old Volkswagen Jetta bearing the markings of the City Administrators, and arm of the Ministry of Public Security. Two people had got out, a fat old man with dyed hair and a shiny suit and a tiny woman in the uniform of the Public Security Bureau.

“Why are you giving the officers trouble?” She asked in heavily accented but perfect English.

“I’m not; they’re trying to take my camera as a fine.”

“Such serious allegations. I’m sure you are mistaken it is a misunderstanding caused by you, I’m sure.”

“Why are you here?”

“I was just walking.”

The skinny man spoke up excitedly, clearly talking about the chalk message. “Let our colleague see your pictures please.”

I show the fat man the images on my camera but I haven’t used the other memory card for a long time and the images of a snowbound England seem incongruous in the Chinese heat. Regardless, the fat man simply shakes his head and shrugs after seeing them.

“This is not right, what you are doing. Who was the man you spoke to?”

“I don’t know I couldn’t understand him. He was angry anyway.”

“What did he give you? What did he tell you?”

“Nothing, seriously.”

“Would you empty your pockets and bag please?”

“No.”

“Pardon? You are causing troubles here!”

She didn’t wait for an answer. “Don’t take photographs of private or public property; this is against the law. Take pictures only of the official scenic spots. Don’t walk around places like this, it is none of your business. Some people spread rumors and say there’s a problem. They are seeking to cause problems and you must stay away from them. Don’t listen to those unharmonious people.”

She went on; “Don’t try to embarrass us. Many foreigners cannot understand the situations in China. China has a long unique history. You don’t understand the Chinese and you may have a wrong idea about the situation. Listen to what I say. China is developing very fast and we are solving all the problems ourselves. Everything is fine. Now give you passport and visa details to Mr. Wu. Apologise to our colleagues for your allegations, and don’t commit such acts again.

The big man in the suit had finished copying the details from my passport and visa and was walking back to the car. He handed it to the woman. “We will remember you, Mr…” There was a pause as she squinted at my name, “err Michael.”

Without another word they got in their respective vehicles and disappeared. I collected my things from the dirt and adjusted the note and memory card in my pants, faintly worrying about papercuts. I turned too and walked away on shaking legs.

The note read: “The government forces us to move within two weeks, many people are unwilling to move because they take away our homes but the money they give us is not enough to buy a new one at all, so we have to get a mortgage. Some people already have difficulties, and if you cannot pay the mortgage you have nowhere to live, so we don’t want to move. Then the government sends thugs to beat up people and smash their things.”

Mao learned quickly from the lessons of Stalin. It was imperative for both of these men to move away from Marxism-Leninism as swiftly as possible. Under the ideology upon which the PRC is founded after a successful ‘proletariat revolution’ and a brief ‘dictatorship of the people’ another ‘bourgeois revolution’ would then bring about another pluralistic socialist revolution. As the landed and affluent middle class grows – as it has exponentially in China over the past few decades – they become and increasingly influential political and economic force.

Struggles over the reform of land-rights have been ripe battlegrounds within the secretive machinations of the country’s leadership. Outspoken proponents of such and other civil reforms have been attacked and vilified both in life and in death – think of Zhao Ziyang’s home imprisonment for the last 15 years of his life or the purge of Peng Dehuai after he spoke about the nation’s massive starvation in the 1960’s.

Eventually in 2007 a new law was passed and whilst it stated that “The Property Law allows for ownership of exclusive parts within an apartment building, which endorses the individual ownership of apartments.” (Article 70). It also maintained that only state backed and approved construction projects can take place but in these cases the official buildings: “As a protection of the right, the term of the right shall be automatically renewed upon expiration” (Article 149). The law also prohibits any foreign company from purchasing or developing land, an effort to avoid ‘Bourneville” stlye conurbations springing up to allow companies to attract a better quality of worker. The key part is article 12 which enshrines the limited lease system and over-rules all other articles pertaining to land use rights. These leases can only be obtained from the central party and have only gone to party insiders.

This all leaves the aforementioned burgeoning middle class in an overtly tough situation. Their rights have not changed yet the country is unrecognizable. They own limited leases on properties in some of the fastest growing cities in the world. They pay billions of dollars in rentals and mortgages to a handful of people and can not guarantee that they will be able to re-new this lease at its conclusion. Land prices in Shanghai alone have increased more than 200 fold since the death of Mao and China has already a property bubble as cartelled prices have outstripped even the country’s rampant inflation yet they show no signs of coming down.

Regardless of the rhetoric and impressions which it may give, China is a feudalist state run by a tiny isolated plutocratic oligarchy, who hold corruption and nepotism in highest regard, at the expense of a massive ‘modern peasant class’. The elite’s children, known as ‘princelings’, drive Ferraris and, literally, get away with murder.

The final aspect of the Party’s control may seem to be a little thing but is in fact the key to maintaining the power all legal questions of property ownership: notaries. Civil Law Notaries may seem a dull part of western beaurocracy but they ensure an independent legal recognition of the purchase and ownership of property. Yet in China only state run banks may offer mortgages on the leases and only the city administrators may offer these leases. This means that the only people able to save properties or enforce ownership are the same people who are in charge of pulling them down and increasing the land values within the cities. This is why no-one in China has effectively defended their home or business property.

One of the most repeated dogmas in China is that, as a rapidly developing country things can not progress as smoothly as in western countries due to the timescale. In fact, China is in the fortunate position of developing in a time when the mistakes have been made before by otters. Yet, the leadership has created a property bubble and crash, an inaccessible housing market and rampant landlordism under the control of a small cabal of party insiders. The social problems this has caused in other countries are well documented but none of those countries has the population size and discrepancies of wealth that China does. There is no welfare state, no free healthcare or even sick leave. There is talk of a minimum wage but it is to be set at 40% of the average for the city making it, infact, a tool to hold down wages.

More than 700 million people in China earn less than $2 a day, half of them less than one. A further 300 million earn less than $6,500 a year and an average flat cost $31 per square metre for rentals alone, residential sales to first time buyers fell to under 10% of the market in 2011. Which, considering there are 7 million university students graduating every year, all of whom are expected to be married by 25 at which point the groom is expected to buy a home for the family, indicates much more serious social problems down the line.

This is one of the biggest of many problems on the horizon for China, combine it with and ageing population, devastating pollution and impeding resource shortages and things look as unpredictable in the future as they did in the past. The Bo Xi Lai scandal may have made the party look briefly unsteady but the arrest of Ai Wei Wei and the exile of Chen GuangCheng show that it will continue to crush its enemies no matter how big or small and when the darkest days come, they may look to their tanks again.

 

© Michael Greenhalgh 2010 (2012)